A member from Jardim Paulista, Brazil, suffered from HACE, HAPE and hyponatremia and was successfully treated and discharged after airborne evacuation. In a related mission, his companion, a 46-year-old woman from the same location, was rescued from Annapurna 1, Camp 3, with life-threatening altitude-related symptoms, including dangerously low oxygen saturation, swelling and hallucinations. She, too, was diagnosed with HACE, HAPE and multiple complications, treated intensively and discharged in stable condition. These back-to-back incidents underscore the severity and unpredictability of conditions on Annapurna.